3D modules also occupy large amounts of factory floor space and therefore absorb a high proportion of factory overheads..
This new API (active pharmaceutical ingredient) manufacturing plant is a flagship facility for Pfizer’s regional network, a $1bn SGD investment covering almost 430,000 square feet and delivered entirely during the COVID-19 pandemic.The facility needed to represent best practice in GMP (good manufacturing practice) and digital automation while remaining cost effective to build and operate.. Bryden Wood was engaged to review and optimise a previously developed concept design for the site’s dry processing (milling and sieving) building.
We worked closely with client stakeholders to analyse the root process requirements, identify over-provisions in the proposed design, and consolidate production onto less equipment.. Capturing these root requirements in 3D digital models called.“Chips” (sets of interacting components.allowed us to rapidly evaluate a wide range of configuration options with client stakeholders engaged every step of the way..
The reduced equipment requirements allowed us to pivot away from the originally proposed central spine corridor towards a simpler configuration of process rooms with perimeter circulation on both sides.This, coupled with extensive deployment of glazing, allowed us to bring natural light to both circulation and process areas, enhancing the workplace environment and employee wellbeing.. Our alternative design for the milling building reduced operational CO. 2. emissions by more than 50% and capital cost by 30%.
It was adopted by Pfizer and incorporated into the delivered scheme.
“The layout, space and light in the milling building is superb,” said Pfizer’s Senior Director of Operations..There is a huge effort ongoing to find replacement sources for aircraft fuel (SAF).
A small amount of this could be diverted to the much more commercially valuable (margin-wise) supply of high purity solvents..Waste recycling within plants is something many manufacturers are looking to increase.
This does not come without quality and technical challenges.Local recycling, which is directly discouraged by some regulations, can increase batch-to-batch cross contamination.
(Editor: Adjustable Steamer)